癌变·畸变·突变 ›› 1998, Vol. 10 ›› Issue (6): 359-360.doi: 10.3969/j.issn.1004-616x.1998.06.008

• 论著 • 上一篇    下一篇

大蒜素改善GJ IC 功能及抗氧化作用的实验研究

罗 阳 吴耕书 张荔彦 杜 晶   

  1. 沈阳医学院生物化学教研室 沈阳110031
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1998-11-30 发布日期:1998-11-30

EXPERIMENTAL RESEARCHON EFFECTOF ALLITRADI ON IMPROVING GJIC AND ANTI2OXIDATION

Luo yang ,Wu Gengshu , Zhang Liyan ,et al   

  1. S henyang Medical College , S henyang , 110031
  • Received:1900-01-01 Revised:1900-01-01 Online:1998-11-30 Published:1998-11-30

摘要: 本文从氧自由基、GJ IC(细胞间缝隙连接通讯) 及DNA 含量三个不同角度观察了大蒜素可显著减轻氧自由基对细胞的毒害,并能解除苯巴比妥对GJ IC 的抑制( P < 0101) ,提示大蒜素有明显的预防苯巴比妥的动物促癌作用及对抗氧自由基损害的功效。

关键词: 大蒜素, 苯巴比妥, 细胞间缝隙连接通讯, 氧自由基

Abstract: The effect of allit radi on improving GJ IC and anti2oxidation was investigated by measuring oxygen f ree radicals , GJ IC(gap junction intercellular communication) and DNA. The result s showed that allit radi could prevent the cytotoxicity by anti2oxidation , relieve the inhibition of phenobarbitone on GJ IC( P < 0101) . It implys that allit radi could prevent the effect of phenobarbitone on promoting carcinogenesis by increasing the GJ IC function , and inhibit the toxic effect of oxygen f ree radicals on hepatocytes.

Key words: Allit radi, phenobarbitone, GJIC, oxygen f ree radicals